Stem Cell Therapy - Autoimmune Diseases

Currently, autoimmune conditions are treated with powerful medications including steroids, methotrexate, cyclosporine, gold, and others. Despite inducing temporary improvement, these approaches possess the possibility of long-term adverse effects, as well as need for life-long treatment. Stem Cell Therapy may help patients who don't respond to typical drug treatment..

The most common autoimmune diseases are:

Crohn's disease

Crohn's disease is a long-term condition that causes inflammation of the lining of the digestive system. Some patients fail to respond to the best clinical treatment in Crohn's disease and some only experience a temporary benefit, which is why the search for more effective treatments is continuing. Recently, an experimental treatment has been developed for severe Crohn's disease, called 'high dose immunoablation followed by autologous hematopoietic stem cell transplantation'. Hematopoietic blood stem cells are young, undifferentiated blood cells that can develop into differentiated ones, including lymphocytes, and over-reactive lymphocytes are thought to contribute to the development of Crohn's disease.

This study involves removing your over-active lymphocytes (immunoablation) and replacing them using blood stem cells that had been taken (harvested) from your body earlier in the study. Conventional medication only temporarily suppresses the over-reactive lymphocytes.

At present, about 30 patients suffering from Crohn's disease have been treated with stem cell transplantation worldwide. The results from those studies suggest that the therapy may be effective, but it cannot be concluded yet whether this treatment is better than any best clinical practice.

Myasthenia gravis

With the lack of effective drug treatments for myasthenia gravis, stem cell treatment has become the number one treatment for this disease. Stem cell therapy is an attractive strategy for neurological diseases and has generated optimism about restoring function or delaying degeneration. Stem cells that are isolated and expanded in culture can be modified to release growth factors and generate glial cells following transplantation into the spinal cord or brain. As such, they might be able to both detoxify the local environment around dying motor neurons and deliver atrophic factors.

With our good clinical efficacy to demonstrate that adult stem cell therapy or umbilical cord mesenchymal stem cells (UCMSC) represents a good chance for treating myasthenia gravis and that intraspinal injection of umbilical cord mesenchymal stem cells (UCMSC) is also safe in the long term. Recently treated cases show promising therapeutic effects in myasthenia gravis without causing any side effects.

Rheumatoid arthritis

The immune system produces antibodies that attach to the linings of joints. Immune system cells then attack the joints, causing inflammation, swelling, and pain. If untreated, rheumatoid arthritis causes gradually causes permanent joint damage.

Multiple sclerosis

The immune system attacks nerve cells, causing symptoms that can include pain, blindness, weakness, poor coordination, and muscle spasms

Chronic Obstructive Pulmonary Disease (COPD)

Today, new COPD stem cell treatments and advances in research are giving new hope to people affected by this disease. The COPD treatments for Stem Cell Clinical Studies are being studied for their efficacy in improving the complications in patients with Chronic Obstructive Pulmonary Disease, through the use of stem cells. These stem cell treatments for COPD may help patients who don't respond to typical drug treatment.

Adipose stem cell therapy is a new alternative treatment to manage the complications of COPD. The stem cells harvested from a patient have the potential to replace countless cells of the body, lung tissue included. These stem cells may heal the body by replacing ones plagued with disease, regenerating new cells, and suppressing the immune systems macrophage response which engulf and digest the dying cells of the lungs. Current research in adult stem cell therapy has shown that restoration of damaged cells through this treatment is possible. This breakthrough in regenerative medicine shines a light of hope on those battling this degenerative disease.

Improvements have been seen in the following symptoms after treatment:

• Reduction of dyspnea (difficult or labored breathing)

• Increased energy

• Increase in the ability to walk alone

• Increase in the ability to perform daily tasks

• Reduction of reliance on supplemental oxygen

• Improvements in sleep patterns

• Enhanced mood

Interstitial Lung Disease (ILD)

It offers stem cell treatments for interstitial lung disease. The stem cells used are autologous, which means they come from the patient's own body. The stem cells are extracted from bone marrow or the patient's blood (venous) depending on the patient's current condition and health history. Adult stem cells have the capacity to form many types of differentiated cells, so when the stem cells are returned to the patient, they will target the damaged tissue, which leads to improved lung function in patients with a chronic lung disease. Our minimally invasive, outpatient stem cell procedures are changing lives by helping patients breathe easier.

Once the desired volume of stem cells are available, they are extracted from the patient's blood or bone marrow. The stem cells are isolated and returned to the patient intravenously or through the use of a nebulizer. Once the cells are returned to the patient, they may begin to slow down the progression of the disease. Since stem cells can continually replicate, the lungs can progressively grow stronger, and patients may see restored lung function.

Ankylosing Spondylitis

Treatment protocols derived using stem cells aspired from bone marrow and adipose tissues will show immediate improvement in the condition of patient. Along with stem cells treatment, few tailored therapeutics can help to cure Ankylosing spondylitis in very short span of time.

However HLA B27 is a gene has been associated with A.S nor have present day medical science provided any treatment for Ankylosing Spondylitis. However the good news is that we have a very promising and fully practically proven treatment is form of stem cell –"Future of Medicine" as we say. Stem cell after transplanting in body differentiates into immune cell and correct the immunity system not only this but also being characterised unique property of regeneration. They damaged the tissue. This treatment of MSC (mesenchymal stem cell) not only halts the progression of diseases but also reverse certain spine condition towards normal.

A thoroughly devised and also revised protocol from time to time has resulted into very effective treatment for A.S.